Neurotoxicity of local anesthetics in dentistry
김은정, 김희영, 안지혜,
소속 상세정보
김은정 ( Kim Eun-Jung ) - Pusan National University Dental Hospital Department of Dental Anesthesia and Pain Medicine
김희영 ( Kim Hee-Young ) - Pusan National University Yangsan Hospital Department of Anesthesia and Pain Medicine
안지혜 ( Ahn Ji-Hye ) - Pusan National University Dental Hospital Department of Dental Anesthesia and Pain Medicine
Abstract
During dental treatment, a dentist usually applies the local anesthesia. Therefore, all dentists should have expertise in local anesthesia and anesthetics. Local anesthetics have a neurotoxic effect at clinically relevant concentrations. Many studies have investigated the mechanism of neurotoxicity of local anesthetics but the precise mechanism of local anesthetic-induced neurotoxicity is still unclear. In addition, it is difficult to demonstrate the direct neurotoxic effect of local anesthetics because perioperative nerve damage is influenced by various factors, such as the anesthetic, the patient, and surgical risk factors. This review summarizes knowledge about the pharmacology of local anesthetics, nerve anatomy, and the incidence, risk factors, and possible cellular mechanisms of local anesthetic-induced neurotoxicity.
키워드
Dentistry; Local Anesthetics; Neurotoxicity
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